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US 2026/0091031 A1Published application
Cgrp receptor antagonists for treating chemotherapy-induced nausea and vomiting (cinv)
OwnerAlberto CHIARUGIinventor
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OwnerAlberto CHIARUGIinventor
Estimating the term…
A method in which gepants (antagonists of calcitonin gene related peptide (CGRP) receptor) are used for direct treatment of nausea and vomiting including chemotherapy-induced nausea and vomiting (CINV). Among them, drugs frequently prompt nausea and vomiting, such as antitumor chemotherapeutics which often cause CINV which in turn can severely compromise efficacy of therapy, as well as patient quality of life. The method uses antagonists of the CGRP receptor recently approved for migraine treatment to target calcitonin gene related peptide (CGRP), a neuropeptide with pleiotypic effects in the human body to prevent and counteract drug-induced nausea and vomiting including CINV.
A method for prevention of chemotherapy-induced nausea and vomiting (CINV) in an individual in need, the method comprising
A method for treating chemotherapy-induced nausea and vomiting (CINV) in an individual in need, the method comprising
A method for prevention or treatment of chemotherapy-induced nausea and vomiting (CINV) in an individual in need, the method comprising administering an effective amount of an antagonist of a CGRP receptor and or a pharmaceutically acceptable formulation thereof to the individual in need, to potentiate the effect of drugs used to prevent or treat chemotherapy-induced nausea and vomiting in the individual.
-6. (canceled)
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