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US 2026/0091022 A1Published application
Pharmaceutical composition for treating fatty liver disease
AssigneeShionogi & Co., Ltd.
InventorsHideo YUKIOKA, Atsuyuki SHIMAZAKI, Tadateru HAMADA, Naoki OHYABU
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Abstract
A pharmaceutical composition for treating and/or preventing fatty liver disease, the pharmaceutical composition comprising a compound represented by Formula (I): wherein R1 is haloalkyl or non-aromatic carbocyclyl, R2 is a hydrogen atom or halogen, R3 is halogen, ring A is a group represented by the formula: -L1- is —O—(CH2)—, —(CH2)2—, or the like, R4 is alkyl or haloalkyl, and R5 is alkylcarbonyl or carbamoyl, or a pharmaceutically acceptable salt thereof.
Claims10
A pharmaceutical composition, comprising:
- a compound represented by Formula (I):
- wherein
- R1 is haloalkyl or non-aromatic carbocyclyl,
- R2 is a hydrogen atom or halogen,
- R3 is halogen,
- ring A is a group represented by the formula:
- -L1- is —O—(CH2)—, —(CH2)2—, —(CH2)—(CF2)—, or —(CF2)—(CH2)— (wherein a left bond is attached to the ring A and a right bond is attached to a group represented by the formula:
- R4 is alkyl or haloalkyl, and
- R5 is alkylcarbonyl or carbamoyl,
- or a pharmaceutically acceptable salt thereof;
- and
- at least one compound selected from the group consisting of obeticholic acid, semaglutide, and resmetirom or a pharmaceutically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.