Modified release gamma- hydroxybutyrate formulations having improved pharmacokinetics
AssigneeFlamel Ireland Limited
InventorsClaire Mégret, Hervé Guillard, Jean-François Dubuisson, Jordan Dubow
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Abstract
Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.
Claims25
A powder to be dispersed in water prior to administration once daily to a human patient in need thereof, wherein the powder comprises oxybate in both immediate-release (IR) and modified-release (MR) particles.
A method of treating a human patient in need thereof, the method comprising:
- orally administering a powder for suspension comprising oxybate to the human patient, wherein the orally administering occurs only once daily.
A powder for suspension that is suitable for administration once daily to a human patient in need thereof, wherein the powder comprises immediate-release (IR) particles comprising oxybate and extended-release (ER) particles comprising oxybate.
A powder for suspension that is suitable for administration once daily to a human patient in need thereof, wherein the powder comprises immediate-release (IR) particles comprising oxybate and delayed-release (DR) particles comprising oxybate.
Dependencies are inferred from the claim text.