Compositions and methods for managing rebound of body weight and metabolic parameters
AssigneeEFIL BioScience Inc.
InventorsJeong-Hoon KIM, Mu Lim CHOI, Kee-Hong KIM
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Abstract
The present invention provides compositions comprising one or more ACAT inhibitors and one or more GLP-1 receptor agonists (GLP-1 RAs). The combination therapy reduces side effects associated with high-dose GLP-1 RA monotherapy and provides durable management of weight loss by suppressing rebound of body weight, blood glucose, and cholesterol levels after treatment.
Claims12
A method for managing body weight and metabolic parameters in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a combination of one or more GLP-1 receptor agonists (GLP-1 RAs) and one or more ACAT inhibitors, wherein the combination therapy is effective to achieve one or more of the following:
- a. delaying and reducing weight regain after cessation of the treatment compared to GLP-1 RA monotherapy;
- b. minimizing or suppressing the rebound in blood cholesterol levels after cessation of the treatment compared to GLP-1 RA monotherapy;
- and
- c. minimizing or suppressing the rebound in blood glucose levels after cessation of the treatment compared to GLP-1 RA monotherapy.
A pharmaceutical composition for managing body weight and metabolic parameters in a subject in need thereof, the composition comprising one or more GLP-1 receptor agonists (GLP-1 RAs) and one or more ACAT inhibitors, wherein the composition is formulated to achieve one or more of the following:
- a. delaying or reducing weight regain after cessation of the treatment compared to GLP-1 RA monotherapy;
- b. minimizing or suppressing the rebound in blood cholesterol levels after cessation of the treatment compared to GLP-1 RA monotherapy;
- and
- c. minimizing or suppressing the rebound in blood glucose levels after cessation of the treatment compared to GLP-1 RA monotherapy.
Dependencies are inferred from the claim text.