Methods of treatment of temozolomide-resistant glioma using coenzyme q10
AssigneeBPGbio, Inc.
InventorsNiven Rajin Narain, Rangaprasad Sarangarajan, Vivek K. Vishnudas, Anne R. Diers, Stephane Gesta
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Abstract
The invention provides methods and compositions for treatment of a subject with a glioma that has failed treatment with temozolomide (TMZ) comprising administration of a composition comprising a Coenzyme Q10 compound to the subject. The invention also provides a method of treating a cancer that exhibits increased Complex II activity in a subject comprising administration of a composition comprising a Coenzyme Q10 compound to the subject.
Claims36
A method of treating a glioblastoma in a subject, the method comprising administering to the subject;
- a) a composition comprising Coenzyme Q10;
- and
- b) temozolomide (TMZ), thereby treating the glioblastoma in the subject, wherein the composition comprising the Coenzyme Q10 is administered by injection or infusion.
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5-8. (canceled)
The method of claim 61, wherein the subject has failed treatment of the glioblastoma with bevacizumab.
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Dependencies are inferred from the claim text.