Back to results
US 2026/0085355 A1Published application
Method for identifying dementia with lewy bodies in a subject
AssigneeAdmit Therapeutics Sl
InventorsMarta BARRACHINA CASTILLO, Jose Luis MOSQUERA MAYO, Marta BLANCH LOZANO
Life of this patent
Estimating the term…
Abstract
It is provided a method for identifying dementia with Lewy bodies (DLB) in a subject, comprising determining in a sample of the subject comprising mitochondrial DNA, the methylation pattern in the D-loop region and/or ND1 gene of the mitochondrial DNA. Further, a classification model, oligonucleotides and kits to perform the method are also provided.
Claims15
A method for identifying dementia with Lewy bodies in a subject, comprising:
- (a) determining in a sample of the subject comprising mitochondrial DNA, the methylation pattern in the D-loop region and/or the ND1 gene of the mitochondrial DNA,
- wherein the methylation pattern is determined in at least one site selected from the group consisting of:
- (i) the CpG sites of the D-loop region shown in Table 1,
- (ii) the CHG sites in the D-loop region shown in Table 3,
- (iii) the CHH sites in the D-loop region shown in Table 5,
- (iv) the CpG sites of the ND1 gene shown in Table 2, and
- (v) the CHG sites of the ND1 gene shown in Table 4,
- and wherein the methylation pattern is determined in at least one of (vi) the CHH sites of the ND1 gene shown in Table 6.
5 more elements
A computer-implemented method for the identification of DLB in a subject, comprising:
- (a) receiving data relating to the methylation pattern in the D-loop region and/or the ND1 gene of the mitochondrial DNA of a subject, wherein the methylation pattern is determined in at least one site selected from the group consisting of:
- (i) the CpG sites in the D-loop region shown in Table 1,
- (ii) the CHG sites in the D-loop region shown in Table 3,
- (iii) the CHH sites in the D-loop region shown in Table 5,
- (iv) the CpG sites of the ND1 gene shown in Table 2, and
- (v) the CHG sites of the ND1 gene shown in Table 4,
- and wherein the methylation pattern is determined in at least one of (vi) the CHH sites of the ND1 gene shown in Table 6,
- and optionally at least one clinical variable of the subject, and
- (b) determining a risk score correlating to the identification of DLB in a subject, wherein the risk score is calculated using a classification model configured to combine the methylation pattern of one or more sites of step (a) and optionally at least one clinical variable of the subject.
6 more elements
Dependencies are inferred from the claim text.