Compositions for use in the treatment of chd2 haploinsufficiency
AssigneeYeda Research and Development Co. Ltd.
InventorsIgor ULITSKY, Caroline Jane ROSS
Life of this patent
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Abstract
A method of increasing an amount of Chromodomain Helicase DNA Binding Protein 2 (CHD2) in a neuronal cell is provided. The method comprising introducing into the cell a nucleic acid agent directed at the last exon of human Chaserr, thereby increasing the amount of CHD2 in the neuronal cell.
Claims33
A method of increasing an amount of Chromodomain Helicase DNA Binding Protein 2 (CHD2) in a neuronal cell, the method comprising introducing into the cell a nucleic acid agent that down-regulates activity or expression of human Chaserr, wherein the nucleic acid agent is directed at the last exon of human Chaserr, thereby increasing the amount of CHD2 in the neuronal cell.
A method of treating a disease or medical condition associated with Chromodomain Helicase DNA Binding Protein 2 (CHD2) haploinsufficiency in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a nucleic acid agent that down-regulates activity or expression of human Chaserr, wherein the nucleic acid agent is directed at the last exon of human Chaserr, thereby treating the disease or medical condition associated with CHD2 haploinsufficiency.
A nucleic acid agent that down-regulates activity or expression of human Chaserr for use in treating a disease or medical condition associated with Chromodomain Helicase DNA Binding Protein 2 (CHD2) haploinsufficiency in a subject in need thereof, wherein the nucleic acid agent is directed at the last exon of human Chaserr.
A nucleic acid agent that activity or expression of human Chaserr, wherein the nucleic acid agent comprises a nucleic acid sequence that hybridizes at the last exon of human Chaserr.
A method of analyzing a set of sequences describing a plurality of homologous polynucleotides, the method comprising:
- constructing a graph having a plurality of nodes arranged in layers, and a plurality of edges connecting nodes of consecutive layers, wherein each layer represents a sequence of the set such that a first layer represents a sequence describing a query polynucleotide, each node represents a k-mer within a respective sequence, and each edge connects nodes representing identical or homologous k-mers, k being from 6 to 12;
- searching said graph for continuous non-intersecting paths along edges of said graph;
- and
- generating an output identifying a k-mer corresponding to at least one path as a nucleic acid sequence of functional interest.
Dependencies are inferred from the claim text.