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AssigneeHospital of Stomatology, Guangzhou Medical University
InventorsJianwen LI, Yunyang LI, Yunqin YAN, Xi XIANG, Lingling OU, Sujuan ZENG, Chaoyang MA, Bo PENG, Xuguang GAO, Janak lal PATHAK
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Disclosed is a use of G007-LK in promoting osteogenic differentiation of dental mesenchymal stem cells and bone tissue regeneration. In vitro experiments of the present application show that G007-LK has the ability to induce SHED to form mineralized nodules and promote osteogenic differentiation; in vivo experiments show that G007-LK pretreatment of SHED for 7 days combined with Geistlich Bio-Oss® collagen bone scaffold can enhance the in vivo osteogenic effect of SHED and promote the subcutaneous ectopic osteogenesis of nude mice, indicating that G007-LK has good osteoinductivity and is a potential osteogenic drug. Therefore, G007-LK can promote osteogenic differentiation of dental mesenchymal stem cells and be applied to bone tissue regeneration.
A use of G007-LK in promoting osteogenic differentiation of dental mesenchymal stem cells, wherein a chemical structure of G007-LK is as follows:
A use of G007-LK in preparing a product for promoting osteogenic differentiation of dental mesenchymal stem cells, wherein a chemical structure of G007-LK is as follows:
A method for inducing osteogenic differentiation of dental mesenchymal stem cells, comprising:
A use of dental mesenchymal stem cells pretreated with G007-LK and bone powder in preparing bone repair products, wherein a chemical structure of G007-LK is as follows:
Dependencies are inferred from the claim text.