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US 2026/0085128 A1Published application
Anti-cd157 antibodies, antigen-binding fragments thereof and compositions and methods for making and using the same
AssigneeBiolegend, Inc.
InventorsSusannah Helene KASSMER-RODRIGUEZ, Weihao CHEN
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Abstract
Compositions and methods for making and using anti-CD157 antibodies or antigen-binding fragments thereof, for example, monoclonal antibodies, CD157-binding antibody fragments, and derivatives are described, as are nucleic acids encoding such molecules, diagnostic reagents and kits that include anti-CD157 antibodies or antigen-binding fragments thereof, and methods of making and using the same.
Claims21
1-19. (canceled)
An isolated antibody or antigen binding fragment thereof that specifically binds to CD157, wherein the isolated antibody comprises:
- a) a heavy chain variable region comprising:
- (i) a heavy chain complementarity determining region 1 (CDRH1) comprising the amino acid sequence SYHVS (SEQ ID NO:
- 17),
- (ii) a heavy chain complementarity determining region 2 (CDRH2) comprising the amino acid sequence IIWTGGSTAYNSLLKS (SEQ ID NO:
- 19), and
- (iii) a heavy chain complementarity determining region 3 (CDRH3) comprising the amino acid sequence SITPTFFDY (SEQ ID NO:
- 21);
- and
- b) a light chain variable region comprising:
- (iv) a light chain complementarity determining region 1 (CDRL1) comprising the amino acid sequence KRSTGNFGSNYVN (SEQ ID NO:
- 24),
- (v) a light chain complementarity determining region 2 (CDRL2) comprising the amino acid sequence RDDKRPD (SEQ ID NO:
- 26), and
- (vi) a light chain complementarity determining region 3 (CDRL3) comprising the amino acid sequence QSYSSGIV (SEQ ID NO:
- 28).
12 more elements
Dependencies are inferred from the claim text.