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AssigneeCompass Therapeutics LLC
InventorsBing GONG, Rachel RENNARD, Amanda Frank OLIPHANT, Cheuk Lun LEUNG, Benjamin Jacob WOLF, Ugur ESKIOCAK, Pearl BAKHRU, Diana I. ALBU
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The present disclosure relates to compositions and methods for inhibiting tumor evasion by reducing immune checkpoint suppression. In some embodiments, provided herein are compositions that block the interaction between PD-1 and its ligand (e.g., PD-1 and/or PD-L2) while promoting the interaction of the cells on which PD-1 and its ligand are expressed. Also provided are methods of using such compositions.
A nucleic acid encoding a multispecific antigen-binding construct comprising at least two antigen-binding arms, wherein:
A multispecific antigen-binding construct comprising four units of antigen-binding, wherein a first and second unit of antigen-binding bind PD-1, and a third and fourth unit of antigen-binding bind PD-L1, wherein the multispecific antigen-binding construct blocks the interaction of PD-1 and PD-L1, and wherein the construct comprises a heavy chain amino acid sequence that is at least 85% identical to the amino acid sequence of SEQ ID NO:
A multispecific antigen-binding construct comprising four units of antigen-binding, wherein a first and second unit of antigen-binding bind PD-1, and a third and fourth unit of antigen-binding bind PD-L1, wherein the multispecific antigen-binding construct blocks the interaction of PD-1 and PD-L1, and wherein the construct comprises a heavy chain amino acid sequence that is at least 85% identical to the amino acid sequence of SEQ ID NOs:
Dependencies are inferred from the claim text.