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US 2026/0085094 A1Published application
Stapled peptide and use thereof
AssigneeJiangsu Deyuan Pharmaceutical Co., Ltd.
InventorsZhixiang PAN, Haiying HE, Zhigan JIANG, Shuhui CHEN
Life of this patent
Estimating the term…
Abstract
A series of stapled peptides and a use thereof, specifically relating to a polypeptide having a sequence as shown in a formulas (I-1)-(I-5) and (II-6), and a pharmaceutically acceptable salt thereof.
Claims13
A polypeptide with a sequence shown in following formula or a pharmaceutically acceptable salt thereof,
- (I-1)
- Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-
- X1-Leu-Asp-Lys-1Lys-Ala-Gln-1Lys-Ala-Phe-Ile-Glu-
- Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-
- Pro-Pro-X2,
- (I-2)
- Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-
- X1-Leu-Asp-1Lys-Lys-Ala-1Lys-Aib-Ala-Phe-Ile-Glu-
- Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-
- Pro-Pro-X2,
- (I-3)
- Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-
- X1-Leu-Asp-Lys-Lys-Ala-Gln-1Lys-Ala-Phe-Lys-Glu-
- Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-
- Pro-Pro-X2,
- (I-4)
- Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-
- X1-Leu-Asp-Lys-Lys-Ala-Gln-Aib-1Lys-Phe-Ile-1Lys-
- Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-
- Pro-Pro-X2,
- (I-5)
- Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-
- X1-Leu-Asp-Lys-Lys-Ala-Gln-Aib-Ala-Phe-Ile-Glu-
- 1Lys-Leu-Leu-1Lys-Gly-Gly-Pro-Ser-Ser-Gly-Ala-
- Pro-Pro-Pro-X2,
- (II-6)
- Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-
- X1-Leu-Asp-Lys-Lys-Ala-Gln-Aib-Ala-Phe-Ile-1Lys-
- Tyr-Leu-1Lys-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-
- Pro-Pro-Pro-X2,
- wherein
- Aib is
- X1 is;
- X2 is selected from
- 1Lys represents a lysine with a modification, wherein the modification is that amino groups on side chains of two lysines are connected to
- X is selected from
- and wherein “*” indicates a position connected to X0;
- X0 is
- m is selected from 2 and 3;
- n is selected from 8, 9, and 10;
- p is selected from 1 and 2.
38 more elements
A polypeptide shown in following formula or a pharmaceutically acceptable salt thereof,
(canceled)
Dependencies are inferred from the claim text.