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US 2026/0085068 A1Published application
A novel crystalline form of pritelivir
AssigneeAssembly Biosciences, Inc.
InventorsZhixin ZONG, Nicole WHITE, Yi WU
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Abstract
The invention relates to a novel crystalline form of pritelivir, as well as to pharmaceutical compositions comprising the same, and to methods for its production and use of the crystalline form in a medicament and for the treatment of herpes virus.
Claims15
A crystalline form of pritelivir, wherein the crystalline form is Type 8 and is characterized by data selected from one or more of the following:
- a) an X-ray powder diffraction (XRPD) pattern measured using Cu Ka (λ=1.5406 Å) comprising peaks at 2-theta values of 10.5 and 24.7°2θ±0.2°2θ;
- and
- b) a DSC thermogram comprising an endothermic event with an onset temperature of 224° C.±2° C.
(canceled)
A process to prepare a crystalline form of pritelivir, wherein the crystalline form is Type 8 and the process comprises the steps of:
- a) providing a solution of pritelivir in a first solvent system;
- b) adding a second solvent system to the solution from step a);
- c) stirring the mixture from step b) for at least 1 hour;
- d) optionally, isolating the solids formed from step c);
- and
- e) optionally, drying the solids isolated from step d).
3 more elements
Dependencies are inferred from the claim text.