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AssigneeKaryopharm Therapeutics Inc.
InventorsErkan Baloglu, Sharon Shacham, William Senapedis, Dilara McCauley, Yosef Landesman, Gali Golan, Ori Kalid, Sharon Shechter
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The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula A, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.
1-86. (canceled)
A method of treating a disorder in a subject in need thereof, wherein the disorder is cancer, a neurodegenerative disease or an immune system disease the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a compound represented by Structural Formula XI:
The method of claim 103, wherein the cancer is Ewing's sarcoma.
A method of treating osteosarcoma in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a compound represented by the following structural formula:
A method of treating childhood rhabdomyosarcoma in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a compound represented by the following structural formula:
A method of treating childhood Ewing's sarcoma in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a compound represented by the following structural formula:
Dependencies are inferred from the claim text.