Degraders of son of sevenless homolog 1

A compound of Formula I or Formula II

• or a pharmaceutically acceptable salt or derivative thereof,
• wherein:
• R1 is aryl optionally substituted with one or more groups independently selected from halo, amino, C1-C6 alkyl, and C1-C6 haloalkyl;
• R2 is selected from H or C1-C6 alkyl;
• R3 and R4 are each C1-C6 alkoxy;
• L is a linker;
• and
• B is an E3 ubiquitin ligase-recruiting moiety.