Dual Function Compounds For NADPH Oxidase Inhibition And Histone Deacetylase Inhibition

A compound of the following Formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein,
• ZBG is a hydroxamic acid group, an ortho-aminoanilide group or a derivative thereof;
• MNox is or comprises a binding moiety that binds to Nox, and has a formula derived from a compound having the following Formula (II):
• and
• L is a bond or a linker covalently coupling MNox and ZBG, and is covalently linked to any location on the MNox,
• wherein,
• A is an aminobenzene moiety, an ortho-dimethoxybenzene moiety, or a benzene moiety;
• B is a phenyl group substituted with one or more nitro, methyl, CF3, halogen, pyrrolidine, OR2, NR3R4, or SO2R3;
• R1 is H or C1-C10 alkyl;
• R2 is methyl, ethyl, n-propyl, or CF3;
• R3 is methyl, ethyl, n-propyl, or CF3;
• R4 is H;
• and
• X is OH or NH2.