Nitrogen-containing heterocyclic derivative inhibitor, preparation method therefor and use thereof

A compound represented by general formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof:

• wherein
• ring A is selected from 5-membered monoheteraryl, 5-membered fused 5-membered bicyclic heteroaryl, 5-membered fused 6-membered bicyclic heteroaryl, 6-membered fused 5-membered bicyclic heteroaryl, or 6-membered fused 6-membered bicyclic heteroaryl;
• ring B is selected from cycloalkyl, heterocyclyl, aryl, or heteroaryl;
• L1 is selected from a bond, —C(O)—, or —C(O)NH—;
• Ra is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, oxo, thio, alkylthio, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)nORA1, —(CH2)nORA1, —(CH2)nC(O) RA1, —(CH2)nC(O)ORA1, —(CH2)nS(O)mRA1, —(CH2)nNRA2RA3, —(CH2)nNRA2C(O)ORA3, —(CH2)nNRA2C(O)(CH2)nRA3, —(CH2)nNRA2C(O)NRA2RA3, —(CH2)nC(O)NRA2(CH2)n1RA3, —OC(RA1RA2)n(CH2)n1RA3, or —(CH2)nNRA2S(O)mRA3, wherein the amino, alkyl, alkenyl, alkynyl, alkylthio, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• RA1-RA3 are each independently selected from hydrogen, deuterium, halogen, nitro, hydroxyl, mercapto, cyano, amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• alternatively, any two adjacent or non-adjacent Ra are connected to form cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• Rb is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, oxo, thio, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)nRB1, —(CH2)nORB1, —(CH2)nC(O) RB1, —(CH2)nC(O)O RB1, —(CH2)nS(O)m RB1, —(CH2)nNRB2RB3, —(CH2)nNRB2C(O)ORB3, —(CH2)nNRB2C(O)(CH2)n1RB3, —(CH2)nNRB2C(O)NRB2RB3, —(CH2)nC(O)NRB2(CH2)n1RB3, —OC(RB1RB2)n(CH2)n1RB3, or —(CH2)nNRB2S(O)mRB3, wherein the amino, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• RB1-RB3 are each independently selected from hydrogen, deuterium, halogen, nitro, hydroxyl, mercapto, cyano, amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• alternatively, any two adjacent or non-adjacent Rb are connected to form cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• alternatively, any two Ra and Rb are connected to form heterocyclyl or heteroaryl, wherein the heterocyclyl and heteroaryl can be optionally further substituted with one or more substituents selected from deuterium, halogen, nitro, hydroxyl, mercapto, cyano, amino, oxo, thio, carboxyl, C1-6 alkyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 alkoxy, C1-6 deuteroalkoxy, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-14 aryl, and 5- to 14-membered heteroaryl;
• Rc is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, oxo, thio, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)nRC1, —(CH2)nORC1, —(CH2)nC(O) RC1, —(CH2)nC(O)O RC1, —(CH2)nS(O)m RC1, —(CH2)nNRC2RC3, —(CH2)nNRC2C(O)ORC3, —(CH2)nNRC2C(O)(CH2)n1RC3, —(CH2)nNRC2C(O)NRC2RC3, —(CH2)nC(O)NRC2(CH2)n1RC3, —OC(RC1RC2)n(CH2)n1RC3, or —(CH2)nNRC2S(O)mRC3, wherein the amino, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• RC1-RC3 are each independently selected from hydrogen, deuterium, halogen, nitro, hydroxyl, mercapto, cyano, amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• alternatively, any two adjacent or non-adjacent Rc are connected to form cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• Rd is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, oxo, thio, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)nRD1, —(CH2)nORD1, —(CH2)nC(O) RD1, —(CH2)nC(O)O RD1, —(CH2)nS(O)m RD1, —(CH2)nNRD2RD3, —(CH2)nNRD2C(O)ORD3, —(CH2)nNRD2C(O)(CH2)n1RD3, —(CH2)nNRD2C(O)NRD2RD3, —(CH2)nC(O)NRD2(CH2)n1RD3, —OC(RD1RD2)n(CH2)n1RD3, or —(CH2)nNRD2S(O)mRD3, wherein the amino, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• RD1-RD3 are each independently selected from hydrogen, deuterium, halogen, nitro, hydroxyl, mercapto, cyano, amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the amino, alkyl, deuteroalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• alternatively, any two adjacent or non-adjacent Rd are connected to form cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• alternatively, any two Rc and Rd are connected to form cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl, and heteroaryl can be optionally further substituted;
• x is 0, 1, 2, or 3;
• y is 0, 1, 2, or 3;
• z is 0, 1, 2, or 3;
• e is 0, 1, 2, or 3
• m is 0, 1, or 2;
• n is 0, 1, 2, 3, or 4;
• and
• n1 is 0, 1, 2, 3, or 4.