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US 2026/0083828 A1Published application
Compositions and methods for treating, ameliorating, and/or preventing diseases and/or disorders
AssigneeYale University
InventorsDemetrios Braddock, Paul Stabach, Ethan Lester
Life of this patent
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Abstract
The present disclosure includes compositions and methods for treating, ameliorating, and/or preventing certain diseases and/or disorders associated with associated with DNAse1 and/or DNAse1L3 deficiency.
Claims33
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A method of treating, ameliorating, or preventing Diffuse Alveolar Hemorrhage (DAH) in a subject, the method comprising administering to the subject a therapeutically effective amount of a construct comprising the amino acid sequence:
- wherein:
- Y is a human DNAse1 polypeptide or a human DNAse1L3 polypeptide;
- X1 is a covalent bond, or X1 is the peptide of amino acid sequence RAFTNNRKSVSLKKRKKGNRS (SEQ ID NO:3), RAFTNNRKSVSLKKRKKGNRSGGVKKPHRYRPGTVAL (SEQ ID NO:54), KQTARKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL (SEQ ID NO:55), or a fragment thereof;
- LINKER is a chemical bond or a polypeptide comprising 1-100 amino acids;
- X2 is null, or X2 is the peptide of amino acid sequence RAFTNNRKSVSLKKRKKGNRS (SEQ ID NO:3) or a fragment thereof;
- Fc is the Fc domain of human IgG1-IgG4.
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Dependencies are inferred from the claim text.