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AssigneeOkinawa Institute of Science and Technology School Corporation
InventorsTetsuya HORI, Tomoyuki TAKAHASHI, Zacharie TAOUFIQ, Kohji TAKEI, Hiroshi YAMADA
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The present invention aims to provide a novel agent for treating Alzheimer's disease, a method for treating Alzheimer's disease, a method for screening for a candidate substance for a therapeutic drug for Alzheimer's disease, and the like. The present invention is a prophylactic and/or therapeutic agent for Alzheimer's disease comprising a peptide corresponding to dynamin 1. The peptide preferably corresponds to dynamin 1-pleckstrin-homology domain or dynamin 1-proline rich domain. In addition, the peptide is preferably encapsulated in nano-particles or linked to a peptide sequence that improve delivery of the peptide into the brain.
1-13. (canceled)
A method for screening for substances effective for the treatment of Alzheimer's disease, comprising a step of measuring an activity of the test substances to inhibit the binding of microtubules and dynamin 1.
A method for treating Alzheimer's disease comprising administering to a patient a peptide corresponding to dynamin 1.
A method for treating Alzheimer's disease comprising administering to a patient an inhibitor of microtubule-dynamin 1 binding.
Dependencies are inferred from the claim text.