Topical Ocular Insulin Delivery Enhanced by Prostaglandin Analogues

Abstract

A pharmaceutical composition is disclosed comprising an insulin, a set of excipients, and a penetration enhancer, wherein the penetration enhancer is a prostaglandin analogue configured to enhance the permeability of insulin upon topical ocular administration. The composition enables increased transport of insulin across ocular tissues, improving absorption and bioavailability following topical delivery to the eye. The formulation includes pharmaceutically acceptable excipients such as surfactants, buffering agents, viscosity enhancers, tonicity agents, preservatives, and solvents suitable for ophthalmic use. The invention provides a non-invasive route of administering insulin through the eye, allowing systemic or local therapeutic effects without injection.

Dependencies are inferred from the claim text.