Engineered Probiotics Expressing Anti-Inflammatory Molecules
AssigneeUniversity of Cincinnati
InventorsNalinikanth Kotagiri, Tushar Madaan
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Abstract
A genetically modified E. coli bacterium is provided where the bacterium expresses a microbial anti-inflammatory molecule (MAM) protein. In one embodiment, the bacterium is a probiotic. In another embodiment, the bacterium is modified is E. coli Nissle 1917. In one embodiment, the MAM protein has a sequence of [SEQ ID NO: 1]. In another embodiment, the bacterium expresses a plasmid having a sequence of [SEQ ID NO: 2].
Claims17
A genetically modified E. coli bacterium wherein the bacterium expresses a microbial anti-inflammatory molecule (MAM) protein.
A plasmid comprising the sequence of [SEQ ID NO:
- 2].
A method of reducing cardiac inflammation in a subject who has experienced a myocardial infarction comprising administering a pharmaceutically effective amount of a genetically modified E. coli bacterium to the subject, wherein the bacterium expresses a microbial anti-inflammatory molecule (MAM) protein.
Dependencies are inferred from the claim text.