COMPOSITIONS AND METHODS FOR TREATMENT OF TRAUMATIC BRAIN INJURY (TBI), FOR EXAMPLE, MILD TRAUMATIC BRAIN INJURY (mTBI)
AssigneeThe Sallie Astor Burdine Breast Foundation
InventorsBrent M. Segal, Catherine Baucom, Xianpeng Jiang
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Abstract
Presented herein are compositions and methods involving mitochondrial organelle transplantation for use in the treatment of traumatic brain injury (TBI), e.g., mild traumatic brain injury (mTBI), in a subject. compositions and methods for treatment of traumatic brain injury (tbi), for example, mild traumatic brain injury (mtbi)
Claims71
A method for allogeneic transplantation of mitochondria in a subject for treatment of traumatic brain injury (TBI), said method comprising administering to said subject a composition comprising mitochondria isolated from a donor other than the subject, wherein the subject has mTBI.
A kit comprising a donor mitochondria composition in a unit dosage effective to treat traumatic brain injury (TBI) in a subject, said donor mitochondria composition comprising:
- mitochondria isolated from tissue of a donor;
- one or more buffering agents;
- a source of magnesium ion;
- a chelating agent;
- a sugar;
- an antioxidant;
- a cytoprotective agent that binds to calcium ion;
- and
- an agent that acts as a membrane stabilizer and/or oxygen radical scavenger and/or binder of Ca2+ and/or binder of free fatty acid.
A method of treating traumatic brain injury (TBI), the method comprising:
- administering to a subject a composition comprising allogeneic mitochondria.
Use of allogeneic mitochondria for the treatment of traumatic brain injury (TBI).
Use of allogeneic mitochondria for the treatment of traumatic brain injury (TBI), wherein the allogeneic mitochondria is administered to a subject suffering from traumatic brain injury (TBI)-associated mitochondrial damage.
Dependencies are inferred from the claim text.