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US 2026/0083778 A1Published application
Generation of cd4 t cells
AssigneeBoston Medical Center Corporation
InventorsGustavo MOSTOSLAVSKY, Julian AMIRAULT
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Abstract
The technology described herein is directed to methods of generating CD4+CD8− single-positive T cells from CD4+CD8+ double positive T progenitor cells using differentiation in the presence of interleukin-7 (IL-7) and an anti-CD3 agent and in absence of Notch ligand and an anti-CD28 agent. Also described herein are CD4+CD8− single-positive T cells made by the methods described herein, which can be used for therapeutic applications.
Claims30
A method of producing a population of CD4+CD8− single-positive (SP) T cells, the method comprising:
- culturing a population of CD4+CD8+ double positive (DP) T progenitor cells in the absence of Notch ligand and an anti-CD28 agent, and in a medium comprising interleukin-7 (IL-7) and an anti-CD3 agent until the population of DP T progenitor cells differentiates into the population of CD4+CD8− SP T cells.
Dependencies are inferred from the claim text.