Methods to treat neurodegenerative disorders by reducing nuclear aggregates and modulating adenosine-to-inosine rna editing
OwnerNandkishore Raghav Belur, Joseph Robert Mazzulliinventors
Life of this patent
Estimating the term…
Abstract
This disclosure provides methods for treating neurodegenerative diseases and restoring neuronal synaptic function by administering adenosine-to-inosine editing modifiers.
Claims20
A method of treating a neurodegenerative disease in a subject in need thereof, the method comprising administering an inhibitor of Adenosine (A) to Inosine (I) RNA editing to the subject.
A method of preventing or dissolving pathological aggregates comprising at least one of NonPOU Domain-Containing Octamer-Binding Protein (NONO) and Splicing Factor, Proline- and Glutamine-Rich (SFPQ) in a cell, the method comprising contacting the cell with an inhibitor of adenosine (A) to inosine (I) RNA editing.
A method of treating a neurodegenerative disease or a neurodevelopmental disorder in a subject in need thereof, the method comprising administering an inhibitor of NEAT1_2 to the subject.
Dependencies are inferred from the claim text.