Composition for enhancing immunity containing amide-based compound
AssigneeAmorepacific Corporation
InventorsEun Jeong CHOI, Geunhyuk JANG, Hyunjung CHOI, Hyoung June KIM, Wonseok PARK, Heungsoo BAEK, Jaewon YOU
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Abstract
The present specification relates to a composition containing a novel amide-based compound derived from an amino acid structure such as valine, leucine, phenylalanine, proline, or pipecolic acid, and the composition can exhibit an immune-enhancing effect by activating the phagocytosis of macrophages, which aids in removing pathogenic bacteria as an important part of the human immune system.
Claims16
A method for enhancing immunity, the method comprising administering an effective amount of a composition containing, as an active ingredient, a compound represented by the following Chemical Formula 1, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof to a subject in need thereof:
- wherein, in Chemical Formula 1,
- X is represented by any one of the following Chemical Formulae 1-1 to 1-5,
- in Chemical Formula 1-1,
- Ar is phenyl unsubstituted or substituted with one to three R1,
- R1 is hydrogen, a phenyl group, a C1-C4 alkoxy group, a C1-C4 alkyl group, a fluoro group, an adamantane group, an acetylamino group, or a hydroxyiminoethyl group,
- when there are more than one R1 residue, all R1 residues are the same as each other,
- in Chemical Formula 1-2,
- Ar is phenyl substituted with one R2,
- R2 is a C1-C4 alkyl group, a C1-C4 alkoxy group, an adamantane group, an acetyl group, or an acetylamino group,
- in Chemical Formula 1-3,
- Ar is phenyl substituted with one to three R3 or unsubstituted naphthalene,
- R3 is hydrogen, or a C1-C4 alkyl group or a phenyl group,
- when there are more than one R3 residue, all R3 residues are the same as each other,
- in Chemical Formula 1-4,
- Ar is phenyl unsubstituted or substituted with one to three R4,
- R4 is hydrogen, a phenyl group, a C1-C4 alkyl group, or a C1-C4 alkoxy group,
- when there are more than one R4 residue, all R4 residues are the same as each other,
- in Chemical Formula 1-5,
- Ar is phenyl substituted with one to three R5,
- R5 is a C1-C4 alkyl group or a phenyl group, and
- when there are more than one R5 residue, all R5 residues are the same as each other.
Dependencies are inferred from the claim text.