Il-17 modulators and uses thereof

A compound according to Formula (IIb),

• or a pharmaceutically acceptable salt thereof,
• wherein:
• B is C1-6 alkyl or C3-10 cycloalkyl, where one or more hydrogens of the alkyl and cycloalkyl are optionally substituted by C3-10 cycloalkyl, C1-6 alkyl, C1-2 alkenyl or halogen, where one or more hydrogens of the alkyl, cycloalkyl and alkenyl are further optionally substituted by halogen or C1-6 alkyl;
• X is CH or N;
• Y1 is N or CR31;
• Y2 is N, NR32 or CR31;
• Y3 is N, NR32, O or S;
• R31 is H, halogen or C1-6 alkyl;
• R32 is C1-6 alkyl, C3-6 cycloalkyl or 4- to 6-membered heterocyclyl, where one or more hydrogens of the alkyl, cycloalkyl and heterocyclyl are optionally substituted by C3-6 cycloalkyl, halogen, C1-6 alkyl, 4- to 6-membered heterocyclyl, —ORb or —NR13R14, where one or more hydrogens of cycloalkyl and heterocyclyl are further optionally substituted by halogen or C1-6 alkyl;
• R1 is C1-6 alkyl, where one or more hydrogens of the alkyl are optionally substituted by halogen, D, CN, 4- to 6-membered heterocyclyl, —ORd or —NR15R16.
• R2 is methyl or cyclopropyl;
• R3 is H, F or —OCH3;
• R6 is 5-membered heteroaryl containing one to three heteroatoms selected from N, O and S, where one or more hydrogens of the heteroaryl are optionally substituted by C1-6 alkyl, fluorinated C1-6 alkyl, deuterated C1-6 alkyl or C3-6 cycloalkyl;
• Rd is H, C1-6 alkyl, C3-6 cycloalkyl or 4- to 6-membered heterocyclyl, where one or more hydrogens of the alkyl, cycloalkyl and heterocyclyl are optionally substituted by F, D, C1-6 alkyl or C3-6 cycloalkyl;
• and
• Rb, R13, R14, R15 and R16 are independently selected from H, C1-6 alkyl and C3-6 cycloalkyl.