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US 2026/0083690 A1Published application
Dispersible formulations of n-((r)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2- fluoro-4-iodo-phenylamino)-benazmide and uses thereof
AssigneeSpringworks Therapeutics, Inc.
InventorsKristin PATTERSON, Jiping LIU
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to dispersible pharmaceutical compositions comprising N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, a pharmaceutically acceptable carrier.
Claims21
1-154. (canceled)
A capsule comprising a dispersible powder comprising:
- a. about 1 mg of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide of Formula (I)
- wherein the N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide constitutes about 0.1 wt/wt % to about 7 wt/wt % of the dispersible powder;
- b. about 50 wt/wt % to about 98 wt/wt % of one or more diluents;
- c. about 1 wt/wt % to about 10 wt/wt % of one or more disintegrants;
- d. optionally one or more flavoring agents;
- e. optionally one or more sweeteners;
- and
- f. about 0 wt/wt % to about 5 wt/wt % of one or more lubricants.
5 more elements
A capsule comprising a dispersible powder comprising:
- a. about 2 mg of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide of Formula (I)
- wherein the N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide constitutes about 0.1 wt/wt % to about 7 wt/wt % of the dispersible powder;
- b. about 50 wt/wt % to about 98 wt/wt % of one or more diluents;
- c. about 1 wt/wt % to about 10 wt/wt % of one or more disintegrants;
- d. optionally one or more flavoring agents;
- e. optionally one or more sweeteners;
- and
- f. about 0 wt/wt % to about 5 wt/wt % of one or more lubricants.
5 more elements
Dependencies are inferred from the claim text.