Device and method for real time assessment and monitoring of thoracic fluid, air trapping and ventilation

A patch for use with a system for monitoring fluid and ventilation status of a patient, the system including an external analysis unit programmed to execute analysis algorithms corresponding to an equivalent electrical model personalized by machine learning algorithms, parameters of the equivalent electrical model being selected from the group comprising an extravascular resistance and capacitance structure, an intravascular resistance and capacitance structure, and a capacitive membrane separating the extravascular and intravascular regions, the patch comprising:

• a disposable adhesive layer configured to be non-invasively disposed on skin of a patient, the adhesive layer including at least four electrodes configured to contact the skin;
• a reusable substrate having an electronics unit configured to be removably coupled to the disposable adhesive layer to couple the electronics unit to the at least four electrodes, the electronics unit having a wireless communications component and a battery, and configured to apply an electrical stimulus simultaneously at a plurality of frequencies in a range up to and including 4.92 MHz through respective pairs of the at least four electrodes to generate a composite response corresponding to a plurality of responses simultaneously measured by the respective pairs at each of the plurality of frequencies,
• wherein the patch includes an alignment marker for positioning the patch adjacent to a sternal notch of the patient, and
• wherein the electronics units is configured to transmit the composite response to the external analysis unit via the communications component, and a display screen associated with the system is configured to display information reflecting the fluid and ventilation status of the patient computed by the analysis algorithms based on the composite response.