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US 2026/0078108 A1Published application
Solid forms of a rock inhibitor
AssigneeRedx Pharma PLC
InventorsAndrew Belfield, Clifford D. Jones, Richard Armer
Life of this patent
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Abstract
This invention relates to a single enantiomer and crystalline forms of a Rho-associated protein kinase (ROCK) inhibitor, useful in the treatment of fibrotic diseases, e.g., fibrostenotic Crohn's disease.
Claims25
The S-enantiomer (S-A) of compound A:
- in substantially enantiopure form, or a pharmaceutically acceptable salt thereof.
A crystalline salt form of compound A:
A method of making HCl crystalline salt form II of a single enantiomer of Compound A, the method comprising:
- a) suspending a sample of HCl crystalline salt form I of a single enantiomer of Compound A in a solvent to form a suspension;
- b) filtering the suspension to obtain HCl crystalline salt form II.
Dependencies are inferred from the claim text.