Biopolymers for Use in Wound Care
AssigneeExoPolymer, Inc.
InventorDerek Wells
Life of this patent
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Abstract
Provided herein are biopolymers comprising repeating polysaccharide units, preparations of biopolymers, and compositions and dressings comprising biopolymers, as well as methods of use.
Claims114
A dressing comprising a biopolymer preparation comprising a biopolymer, wherein the biopolymer is composed of repeating disaccharide units comprising glucose and galactose, wherein at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, or at least 90% of the glucose is acetylated, and wherein at least 40%, at least 45%, at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, or at least 99% of the galactose is pyruvylated, and
- wherein the biopolymer preparation is incorporated on or in a solid substrate.
A dressing comprising a biopolymer preparation comprising a biopolymer that is composed of repeating disaccharide units of the structure:
- wherein the dotted lines represent the bonds between disaccharide units;
- wherein no more than 40%, no more than 35%, no more than 30%, no more than 25%, no more than 20%, no more than 15%, no more than 10%, or no more than 5% of the disaccharide units lack the acetyl moiety;
- and wherein no more than 60%, no more than 55%, no more than 50%, no more than 45%, no more than 40%, no more than 35%, no more than 30%, no more than 25%, no more than 20%, no more than 15%, no more than 10%, no more than 5%, or no more than 1% of the disaccharide units lack the pyruvyl moiety, and wherein the biopolymer preparation is incorporated on or in a solid substrate.
The dressing of any one of the preceding claims, wherein the biopolymer preparation is capable of absorbing at least the same amount, at least 1.5-fold, at least 2-fold, or at least 3-fold more water than an equal amount of hyaluronic acid.
The dressing of any one of the preceding claims, wherein the biopolymer preparation is capable of absorbing an amount of water that is at least 100%, at least 200%, at least 300%, at least 400%, or at least 500% the initial dry weight of the biopolymer preparation.
The dressing of any one of the preceding claims, wherein the biopolymer preparation is less than 25%, less than 20%, less than 15%, less than 10%, less than 5%, less than 3%, or less than 1% succinoglycan, or is substantially free of succinoglycan.
The dressing of any one of the preceding claims, wherein the biopolymer preparation is a powder or rehydrated powder.
A dressing comprising a biopolymer preparation comprising a biopolymer that is composed of repeating disaccharide units comprising glucose and galactose, wherein at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, or at least 90% of the glucose is acetylated, and wherein less than 15%, less than 10%, or less than 5% of the galactose is pyruvylated, and wherein the biopolymer preparation is incorporated on or in a solid substrate.
A dressing comprising a biopolymer preparation, wherein the biopolymer is composed of repeating disaccharide units of the structure:
- wherein the dotted lines represent the bonds between disaccharide units;
- wherein no more than 40%, no more than 35%, no more than 30%, no more than 25%, no more than 20%, no more than 15%, no more than 10%, or no more than 5% of the disaccharide units lack the acetyl moiety;
- and wherein no more than 15%, no more than 10%, or no more than 5%, of the disaccharide units are pyruvylated, and wherein the biopolymer preparation is incorporated on or in a solid substrate.
A dressing comprising a biopolymer preparation comprising a biopolymer that is composed of repeating polysaccharide units of the structure:
- wherein the dotted lines represent the bonds between polysaccharide units;
- wherein no more than 30%, no more than 25%, no more than 20%, no more than 15%, no more than 10%, no more than 5%, or no more than 1% of the polysaccharide units lack an acetyl moiety;
- and wherein no more than 10%, no more than 5%, or no more than 1% of the polysaccharide units lack the pyruvyl moiety, and wherein the biopolymer preparation is incorporated on or in a solid substrate.
A dressing comprising a biopolymer preparation comprising a biopolymer that is composed of repeating polysaccharide units, wherein each polysaccharide unit comprises 2-15 or 2-12 or 2-10 monosaccharides, and wherein the biopolymer has a negative charge:monosaccharide ratio in the repeating polysaccharide unit of at least 0.3, or at least 0.35, or at least 0.4, or at least 0.45, and wherein the biopolymer preparation is incorporated on or in a solid substrate.
The dressing of any one of the preceding claims, wherein the dressing is a wound dressing.
The dressing of any one of the preceding claims, wherein the dressing is skin dressing.
The dressing of any one of the preceding claims, wherein the dressing is a bandage.
The dressing of any one of the preceding claims, wherein the biopolymer preparation forms one layer of the dressing.
The dressing of any one of the preceding claims, wherein the solid substrate comprises woven materials of natural or synthetic fibers or synthetic polymeric sheets.
The dressing of any one of the preceding claims further comprising an adhesive material.
The dressing of any one of the preceding claims further comprising one or more additional ingredients selected from the group consisting of an additional hydrocolloid agent, alcohol, peroxide, betadine, sequestration agents, antimicrobials, antibacterials, antivirals, antifungals, anti-inflammatories, wound healing promoters, conditional agents, surfactants, anti-scaring medications, analgesics, anesthetics, and steroids.
The dressing of any one of the preceding claims, wherein the biopolymer preparation is dispersed throughout a hydrophilic polyurethane foam matrix, and the hydrophilic polyurethane foam matrix is incorporated on or in the solid substrate.
The dressing of any one of the preceding claims, wherein the dressing is a multi-layered dressing.
A method of treating a wound in a subject in need thereof, comprising applying the dressing of any one of the preceding claims to the wound.
A method of treating a wound in a subject in need thereof, comprising applying a composition to the wound, wherein the composition comprises a biopolymer, wherein the biopolymer is composed of repeating disaccharide units comprising glucose and galactose, wherein at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, or at least 90% of the glucose is acetylated, and wherein at least 40%, at least 45%, at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, or at least 99% of the galactose is pyruvylated.
A method of treating a wound in a subject in need thereof, comprising applying a composition to the wound, wherein the composition comprises a biopolymer, wherein the biopolymer is composed of repeating disaccharide units of the structure:
- wherein the dotted lines represent the bonds between disaccharide units;
- wherein no more than 40%, no more than 35%, no more than 30%, no more than 25%, no more than 20%, no more than 15%, no more than 10%, or no more than 5% of the disaccharide units lack the acetyl moiety;
- and wherein no more than 60%, no more than 55%, no more than 50%, no more than 45%, no more than 40%, no more than 35%, no more than 30%, no more than 25%, no more than 20%, no more than 15%, no more than 10%, no more than 5%, or no more than 1% of the disaccharide units lack the pyruvyl moiety.
A method of treating a wound in a subject in need thereof, comprising applying a composition to the wound, wherein the composition comprises a biopolymer, wherein the biopolymer is composed of repeating disaccharide units comprising glucose and galactose, wherein at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, or at least 90% of the glucose is acetylated, and wherein less than 15%, less than 10%, or less than 5% of the galactose is pyruvylated.
A method of treating a wound in a subject in need thereof, comprising applying a composition to the wound, wherein the composition comprises a biopolymer, wherein the biopolymer is composed of repeating disaccharide units of the structure:
- wherein the dotted lines represent the bonds between disaccharide units;
- wherein no more than 40%, no more than 35%, no more than 30%, no more than 25%, no more than 20%, no more than 15%, no more than 10%, or no more than 5% of the disaccharide units lack the acetyl moiety;
- and wherein no more than 15%, no more than 10%, or no more than 5%, of the disaccharide units are pyruvylated.
A method of treating a wound in a subject in need thereof, comprising applying a composition to the wound, wherein the composition comprises a biopolymer, wherein the biopolymer is composed of repeating polysaccharide units of the structure:
- wherein the dotted lines represent the bonds between polysaccharide units;
- wherein no more than 30%, no more than 25%, no more than 20%, no more than 15%, no more than 10%, no more than 5%, or no more than 1% of the polysaccharide units lack an acetyl moiety;
- and wherein no more than 10%, no more than 5%, or no more than 1% of the polysaccharide units lack the pyruvyl moiety.
A method of treating a wound in a subject in need thereof, comprising applying a composition to the wound, wherein the composition comprises a biopolymer, wherein the biopolymer is composed of repeating polysaccharide units, wherein each polysaccharide unit comprises 2-15 or 2-12 or 2-10 monosaccharides, and wherein the biopolymer has a negative charge:monosaccharide ratio in the repeating polysaccharide unit of at least 0.3, or at least 0.35, or at least 0.4, or at least 0.45.
Dependencies are inferred from the claim text.