Methods and compositions for imaging malignancies in the bone marrow
OwnerMonica SHOKEEN, Samuel ACHILEFUinventors
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Abstract
Compositions, methods of synthesis, and methods of use for an imaging agent that preferentially binds to activated VLA4, including, but not limited to a peptide or peptidomimetic ligand radiolabeled for use in PET imaging to identify bone marrow malignancies, help select treatments for bone marrow malignancies, and monitor relapse in bone marrow malignancy patients after therapy are disclosed.
Claims25
An imaging agent composition, comprising a targeting ligand covalently attached to or complexed with a radionuclide binding structure, the targeting ligand configured to preferentially bind activated VLA4, and the radionuclide binding structure configured to bind or complex to a radionuclide.
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Dependencies are inferred from the claim text.