Method for increasing dispersion stability of nanoparticles as t1 mri contrast agent and t1 mri contrast nanoparticles
AssigneeInventera Inc.
InventorsJin Woo CHEON, Tae Hyun Shin
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Abstract
The present invention improves an existing contrast agent, especially, a T1 contrast agent, and adopts a strategy in which the T1 contrast material is partially coated on a support surface to which a hydrophilic functional group is exposed. The partial coating strategy adopted in the present invention improves both the stability and contrast performance of T1 contrast agent nanoparticles, and such a strategy leads to very interesting technical development.
Claims20
A nanoparticle drug carrier comprising a cross-linked polysaccharide support particle that (i) is formed by reacting the polysaccharide with an epoxide cross-linker and an amine cross-linker, (ii) has hydrophilic functional groups on its surface, including amine groups, and (iii) has a hydrodynamic size of 1-8 nm;
- wherein at least a portion of the surface amine groups are substituted with carboxyl groups.
A method of making a nanoparticle drug carrier, comprising:
- (a) cross-linking a polysaccharide by reacting it with an epoxide cross-linker and an amine cross-linker to afford support particles exposing surface amine groups and having a hydrodynamic size of 1-8 nm;
- and (b) substituting at least a portion of the surface amine groups with carboxyl groups.
Dependencies are inferred from the claim text.