Methods For Reducing Or Preventing SARS-COV-2 Infection And Transmission

A method of preventing or reducing transmission of a SAR-Cov-2 variant from a first subject infected with the variant to a second subject who contacts the first subject and is uninfected with the variant before the contact, the method comprising administering to the first subject an effective amount of a peptide conjugate having the formula:

• (Peptide-Linker)n-B-Hydrophobic Moiety
• wherein each Peptide is independently a therapeutic peptide or a targeting peptide, provided that at least one Peptide is a therapeutic peptide,
• each Linker is independently an optional bivalent linking moiety,
• B is a multivalent moiety,
• Hydrophobic Moiety is a lipid or derivative thereof, and
• n is an integer selected from 1, 2, 3 or more;
• and
• wherein the variant comprises at least 5 mutations wherein the at least 5 mutations are independently in the spike protein S1 subunit or the S2 subunit or combinations thereof.