Compositions and methods for treatment of cardiac disorders
AssigneeUniversity of Massachusetts
InventorsKevin Donahue, Phillip Tai, Guangping Gao
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Abstract
Some aspects of the disclosure provide truncated potassium voltage-gated channel subfamily H member 2 (KCNH2) proteins. In some aspects, the disclosure provides nucleic acid regulatory elements comprising (i) an atrial natriuretic peptide (Anf) promoter and (ii) an enhancer element, wherein the enhancer element is not a naturally-occurring Anf enhancer element.
Claims23
A truncated potassium voltage-gated channel subfamily H member 2 (KCNH2) protein comprising one or more dominant-negative mutations relative to a wild-type KCNH2 protein and having a length of 500 to 1,150 amino acids.
13-14. (canceled)
19-20. (canceled)
A nucleic acid regulatory element comprising (i) an atrial natriuretic peptide (Anf) promoter and (ii) an enhancer element, wherein the enhancer element is not a naturally-occurring Anf enhancer element.
23-26. (canceled)
Dependencies are inferred from the claim text.