Long-acting liposomal composition for treatment of pain in articular disorders

A method of treating a subject having an articular disorder, the method comprising administration of a single intra-articular injection of a liposomal composition comprising a plurality of liposomes comprising a phospholipid as the sole active ingredient, wherein the phospholipid comprises a phosphatidylcholine selected from the group consisting of 1,2-dimyristoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-dipentadecanoyl-sn-glycero-3-phosphocholine, 1,2-distearoyl-sn-glycero-3-phosphocholine, N-palmitoyl-D-erythro-sphingosylphosphorylcholine, and a combination thereof, wherein the subject has baseline weekly average of daily joint pain score by visual analog scale ≥50 mm, wherein the method comprises a weekly average of daily joint pain score by visual analog scale reduction of at least 5 compared to a baseline or untreated control, and wherein the method provides a pain relief to the subject which is manifested by a reduction from baseline or untreated control of at least 15 as determined by average of global pain achieved at about 26 weeks following administration.