Compositions for preventing and treating infection comprising an artificial sweetener
AssigneeBrunel University London
InventorRonan McCarthy
Life of this patent
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Abstract
Compositions for preventing and treating bacterial infections include artificial sweeteners such as ace-k, saccharin and cyclamate. The compositions are particularly envisaged for topical administration for treating skin infections and for treating or preventing infections caused by Pseudomonas aeruginosa and/or Acinetobacter baumannii. Compositions including artificial sweeteners at sub-minimum inhibitory concentrations can also be used to disrupt virulence or increase the sensitivity of antibiotic-resistant bacteria to those antibiotics.
Claims44
A composition including an active agent in an amount sufficient to inhibit bacterial growth and/or virulence, wherein the active agent is an artificial sweetener or a chemically related derivative thereof, for use in a method of treating and/or preventing infection.
A composition including an active agent in an amount sufficient to inhibit bacterial growth and/or virulence, wherein the active agent is ace-K, saccharin, cyclamate, sucralose, a sugar alcohol or a chemically related derivative thereof, for use in a method of treating and/or preventing infection.
A composition for use as claimed in any preceding claim, wherein the infection is a bacterial infection caused by Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumoniae, Stenotrophomonas maltophilia, and/or Enterobacter species.
A composition for use as claimed in any preceding claim, wherein the infection is a bacterial infection caused by Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus aureus, Stenotrophomonas maltophilia, and/or Enterobacter species.
A composition for use as claimed in any preceding claim, wherein the infection is a bacterial infection caused by Pseudomonas aeruginosa and/or Acinetobacter baumannii.
A composition for use as claimed in any preceding claim, wherein biofilm formation is inhibited.
A composition for use as claimed in any preceding claim, wherein bacterial motility is inhibited.
A composition for use as claimed in any preceding claim, wherein the bacterial membrane is disrupted.
A composition including an active agent, wherein the active agent is ace-K, cyclamate, saccharin, or a chemically related derivative thereof, for use in increasing susceptibility of bacteria to antibiotic treatment.
A composition for use as claimed in any preceding claim, wherein the active agent is present below a minimum inhibitory concentration.
A composition for use as claimed in any preceding claim, wherein the active agent is present at less than 15% (w/v).
A composition for use as claimed in any preceding claim, wherein the active agent is present at less than 10% (w/v).
A composition for use as claimed in any preceding claim, wherein the active agent is present at less than 5% (w/v).
A composition for use as claimed in any preceding claim, wherein the active agent is present at 3% (w/v) or less than 3% (w/v).
A composition for use as claimed in any preceding claim, wherein the active agent is present at 1.5% (w/v) or less than 1.5% (w/v).
A composition for use as claimed in any preceding claim, wherein the active agent is present at 1% (w/v) or less than 1% (w/v).
A composition for use as claimed in any preceding claim, wherein the composition is formulated for application to a patient's skin.
A method of preventing and/or treating infection, including providing a composition including an artificial sweetener or a chemically related derivative thereof in an amount sufficient to inhibit bacterial growth and/or disable a virulence mechanism, and administering the composition to a patient in need thereof.
A method of increasing the susceptibility of bacteria to antibiotic treatment including:
- providing a composition including an active agent, wherein the active agent is ace-K, cyclamate, saccharin, or a chemically related derivative thereof;
- providing an antibiotic;
- and
- administering the composition and the antibiotic to a subject in need thereof.)
Dependencies are inferred from the claim text.