Compounds and methods for treating diseases caused by SARS-CoV-2 and other coronaviruses

A method of treating a disease caused by SARS-CoV-2 and other coronaviruses comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula I:

• or a pharmaceutically acceptable salt thereof;
• wherein:
• each X, Y, and Z is independently selected from N or C—R2;
• each R1, R2, and R3 is independently from the group consisting of hydrogen, halogen, nitro, cyano, hydroxyl, amino, alkyl, cycloalkyl, optionally substituted cycloalkyl, (cycloalkyl)alkyl, bicycloalkyl, spiroalkyl, optionally substituted alkyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, alkylthio, alkoxyalkyl, (cyano)alkyl, alkenyl, optionally substituted alkenyl, alkynyl, cycloalkylenyl, optionally substituted alkynyl, sulfonamide, alkylcarbonyl, arylcarbonyl, alkylsulfonyl, arylsulfonyl, mercaptoalkyl, carboxy, carboxamido, ureido, (heterocyclo)alkyl, (heteroaryl)alkyl, (amino)(heteroaryl)alkyl, (amino)(aryl)alkyl, heteroalkyl, heterocyclo, optionally substituted heterocyclo, hetero-substituted cycloalkyl, hetero-substituted bicycloalkyl, heteroaryl, optionally substituted heteroaryl, hetero-substituted spiroalkyl, aryl, optionally substituted aryl, N-substituted optionally substituted aryl, N-substituted heteroaryl, N-substituted optionally substituted heteroaryl, aryloxy, heteroaryloxy, aralkyloxy, alkylamino, dialkylamino, hydroxyalkylamino, cycloalkylamino, aralkylamino, (cycloalkyl)alkylamino, aralkyl, (aryl)alkyl, (heterocyclo)alkylamino, (amino)alkyl, heteroalkylenyl, heterocyclenyl, N-aminoacid,
• and
• R1 and R2 could be the same, but, in this case, always different from R3,
• wherein:
• each Ra, Rb, and Rc independently selected from the group consisting of hydrogen, C1-C16 alkyl, or an optionally substituted alkyl, aryl, optionally substituted aryl, and heteroalkyl.