Prevention and treatment of conditions using ethyl pyruvate
AssigneeThe Trustees of Columbia University in the City of New York
InventorsSimon W.M. JOHN, Nicholas TOLMAN
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Abstract
Methods of treating or preventing conditions in a subject are disclosed, the methods including administering to the subject a therapeutically effective amount of ethyl pyruvate, or a derivative or analog thereof, or a pharmaceutical composition thereof. Methods of treating or preventing conditions in a subject including administering to the subject a therapeutically effective amount of ethyl pyruvate, or a derivative or analog thereof, or a pharmaceutical composition thereof, and one or more additional therapeutic agents, are described.
Claims36
A method of treating or preventing a condition in a subject, the method comprising administering to the subject a therapeutically effective amount of ethyl pyruvate, or a derivative or analog thereof, or a pharmaceutical composition thereof;
- wherein the condition is selected from the group consisting of an ocular disease or disorder, a neurodegenerative disease or disorder, a vascular disease or disorder, a metabolic disease or disorder, an inflammatory disease or disorder, a disease or disorder involving abnormal cell death or oxidation, a disease or disorder linked to one or more Lmx1b mutations, and a combination thereof.
A method of reducing or preventing elevated intraocular pressure, the method comprising administering a therapeutically effective amount of ethyl pyruvate, or a derivative or analog thereof, or a pharmaceutical composition thereof, to the subject.
A method of reducing or preventing damage or dysfunction to a subject's eye tissues, the method comprising administering a therapeutically effective amount of ethyl pyruvate, or a derivative or analog thereof, or a pharmaceutical composition thereof, to the subject.
A method of reducing or preventing damage or dysfunction to tissues involved in ocular fluid drainage in a subject, the method comprising administering a therapeutically effective amount of ethyl pyruvate, or a derivative or analog thereof, or a pharmaceutical composition thereof, to the subject.
A method of reducing or preventing developmental malformations or dysfunctions in a subject's eye, the method comprising administering a therapeutically effective amount of ethyl pyruvate, or a derivative or analog thereof, or a pharmaceutical composition thereof, to the subject.
Dependencies are inferred from the claim text.