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US 2026/0076931 A1Published application
L-dopa microbiome therapy
AssigneeIowa State University Research Foundation, Inc.
InventorsANUMANTHA G. KANTHASAMY, Ahmed Abdalla, Gregory Phillips, Nicholas John Backes
Life of this patent
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Abstract
The present invention generally provides methods and compositions for the treatment of Parkinson's disease and depression and/or anxiety. The invention relates to recombinant microorganisms, particularly gut-colonizing probiotics, modified to produce L-DOPA.
Claims20
An hpaB and hpaC nucleotide sequence comprising SEQ ID NO:
- 1 and 2 or as set forth in SEQ ID NO:
- 3 operably linked to a heterologous promoter sequence.
An hpaB nucleotide sequence comprising SEQ ID NO:
- 1 or as present in SEQ ID NO:
- 3 operably linked to a heterologous promoter.
A hpaC nucleotide sequence comprising SEQ ID NO:2 or as present in SEQ ID NO:
- 3 operably linked to a heterologous promoter.
Dependencies are inferred from the claim text.