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US 2026/0076927 A1Published application
Palatable compositions including sodium phenylbutyrate and uses thereof
AssigneeAcer Therapeutics Inc.
InventorsLeah E. Appel, Joshua R. Shockey, D. Christopher Schelling
Life of this patent
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Abstract
The present invention features palatable pharmaceutical compositions including sodium phenylbutyrate and methods for the treatment of inborn errors of metabolism (e.g., Maple Syrup Urine Disease or Urea Cycle Disorders), neurodegenerative disorders such as Parkinson's disease, spinal muscular atrophy, dystonia, or inclusion-body myositis with such compositions.
Claims25
1-30. (canceled)
A composition for oral administration of sodium phenylbutyrate comprising:
- greater than 60% by total weight sodium phenylbutyrate,
- a taste-mask coating,
- wherein the taste-mask coating is insoluble at pH 6-8 and soluble at a pH of less than 5, and
- where the pharmaceutical composition comprises about 5% to 25% by total weight taste-mask coating;
- wherein the pharmaceutical composition is formulated as a tablet.
2 more elements
A method of treating an inborn error of metabolism in a patient in need thereof, the method comprising the step of:
- administering to the patient in need thereof a composition comprising:
- greater than 60% by total weight sodium phenylbutyrate;
- 5% to 25% by total weight taste-mask coating,
- wherein the taste-mask coating is insoluble at pH 6-8 and soluble at a pH of less than 5, and
- wherein the pharmaceutical composition is formulated as a tablet.
2 more elements
Dependencies are inferred from the claim text.