Compounds for use in organ preservation and organ transplantation
AssigneeAbrexa Pharmaceuticals, Inc.
InventorsJesus Ernesto VILLAFRANCA, Charles Richard KISSINGER
Life of this patent
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Abstract
Presented herein, in certain aspects, are methods of preventing, reducing, delaying or inhibiting rejection, injury or partial or complete death of an organ prior to, during or after transplantation into an organ transplant recipient. The methods may comprise administering one or more compositions or compounds disclosed herein to an organ donor or to the organ transplant recipient. The methods may also comprise contacting an organ prior to, during and/or after transplantation, with one or more compositions or compounds disclosed herein.
Claims16
A method for inhibiting, reducing, delaying or preventing rejection, injury or cell death of a transplanted organ in a subject comprising administering to the subject a composition comprising a therapeutically effective amount of a compound having the structure of Formula I;
- or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof,
- wherein:
- R2 is selected from the group consisting of H and methyl;
- R3 is trifluoromethyl or other fluoro substituted alkyl;
- L3 is a carbonyl;
- and
- R6 at each occurrence is independently selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxyl, alkoxy, substituted alkoxy, aryloxy, substituted aryloxy, mercapto, alkylthio, arylthio, carbonyl, aryl, substituted aryl, substituted heterocyclic, halogen, cyano, cyanoalkyl, nitro, amino, amidino, carbamate, S(O)nR7 and C(O)R8 or two R6 at adjacent positions combine to form an optionally substituted heteroaryl or heteroalkyl ring fused with the adjoining phenyl moiety;
- R7 is H, R9, NH2, HNR9 or NR9R10;
- R8 is OH, OR9, NH2, NHR9 or NR9R10;
- R9 and R10 at each occurrence are independently optionally substituted alkyl;
- and
- n=1 or 2.
A ex vivo or in vitro method of preparing an organ for transplantation into a subject comprising contacting the organ with a composition comprising an effective amount of a compound that comprises the structure of Formula IV;
- or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof.
An in situ or in vivo method of preparing an organ for transplantation comprising contacting the organ prior to removal from a donor subject with a composition comprising an effective amount of a compound that comprises the structure of Formula IV,
- or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof.
Dependencies are inferred from the claim text.