Layer-by-layer delivery of active agents
AssigneeLuna Labs USA, LLC
InventorsYang XU, Ziyou ZHOU, Brad BROOKS, Christopher K. TISON
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Abstract
Provided herein are pharmaceutical compositions comprising chitosan based nanoparticles, such as those having a core-shell structure, which can be configured for layer-by-layer delivery of active agent(s).
Claims54
A pharmaceutical composition comprising nanoparticles having a core-shell structure, wherein the nanoparticles comprise a crosslinked polymer comprising a cationic chitosan and an anionic cross-linker, wherein the nanoparticles have an average particle size of about 40 nm to about 1 μm as determined by Dynamic Light Scattering.
A modified release formulation comprising:
- (1) drug-loaded nanoparticles having a core-shell structure, wherein the drug-loaded nanoparticles comprise a crosslinked polymer comprising a cationic chitosan and an anionic cross-linker, a first active agent, and a second active agent;
- and
- (2) a layer coating the drug-loaded nanoparticles;
- wherein the first active agent is encapsulated within the drug-loaded nanoparticles and the second active agent is adsorbed on the surface of the drug-loaded nanoparticles, wherein the first and second active agents can be the same or different active agents, and
- wherein the drug-loaded nanoparticles have an average particle size of about 40 nm to about 1 μm as determined by Dynamic Light Scattering.
A method of stabilizing an active agent for storage comprising (1) mixing a cationic chitosan, an anionic cross-linker, and the active agent to form core-shelled nanoparticles encapsulating the active agent;
- and optionally (2) coating the core-shelled nanoparticles obtained in (1).
Dependencies are inferred from the claim text.