Modified release formulation comprising capsaicinoids and a process

Abstract

The present invention relates to a modified release capsaicinoids formulation comprising of active core, at least one emulsifier and at least one gastro-resistant pH dependent polymer. The active core may be coated with at least one release modifying agent and optionally the outermost coating. The invention as described herein also relates to the solvent-free process, wherein emulsion comprising capsaicinoids is entrapped in at least one gastroresistant pH dependent polymer and deposited on non-pareil seeds to get active core, which may be further coated using at least one release modifying agent to get the beadlets. The formulation releases not more than 10% by weight of capsaicinoids in stomach within 2 hours, followed by release of not less than 75% of capsaicinoids in the intestine within 1 hour. The modified release formulation does not exhibit the alcohol dose dumping effect in stomach and it is safe for oral administration to the consumers.

Dependencies are inferred from the claim text.