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US 2026/0076907 A1Published application
Compositions and methods for compartment-specific cargo delivery
AssigneeFlagship Pioneering Innovations V, Inc.
InventorsGeoffrey A. von Maltzahn, John Miles Milwid, Jacob Rosenblum Rubens, Michael Travis Mee, Neal Francis Gordon, Jagesh Vijaykumar Shah, Kyle Marvin Trudeau, Brigham Jay Hartley
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Abstract
Fusosome compositions and methods are described herein.
Claims20
A fusosome comprising:
- (a) a lipid bilayer comprising a plurality of lipids obtained from a source cell;
- (b) a lumen surrounded by the lipid bilayer;
- (c) a fusogen that is exogenous or overexpressed relative to the source cell, wherein the fusogen is disposed in the lipid bilayer, and wherein the fusogen comprises a paramyxoviral fusogen;
- and
- (d) a nuclear payload agent for delivery to the nucleus of a target cell, wherein the nuclear payload agent comprises a nucleic acid sequence encoding an antibody molecule.
2 more elements
Dependencies are inferred from the claim text.