Back to results
US 2026/0076900 A1Published application
Ipratropium delivery compositions, devices and methods
AssigneeSolstice Advanced Materials US, Inc.
InventorsErik Boldt, Gregory Laurence Smith
Life of this patent
Estimating the term…
Abstract
Disclosed are medicinal compositions, and devices, methods and systems which provide ipratropium bromide carried by at least 1234ze(E) and ethanol.
Claims20
A pressurized metered dose inhaler (pMDI) comprising:
- a. a container;
- b. a pharmaceutical formulation under pressure in the container, said pharmaceutical formulation comprising:
- (i) about from about 75% by weight to about 95% by weight of HFO-1234ze(E);
- (ii) from about 5% by weight to about 25% by weight of ethanol;
- and (iii) ipratropium bromide in solution in said ethanol and/or said HFO-1234ze;
- and
- c. a normally closed valve on the container
- d. an actuator fluidly connected to the valve and having an orifice diameter of less than 0.5 mm, said valve being actuatable to an open position to release said pharmaceutical formulation to pass through said orifice and produce an aerosol spray containing ipratropium bromide in solution.
5 more elements
A method of delivering a dose of ipratropium bromide to the respiratory tract of an animal comprising:
- a. providing in a pMDI comprising:
- i. a canister;
- ii. a formulation comprising ipratropium bromide in solution contained in the canister, said formulation comprising:
- (1) from about 75% by weight to about 88% by weight of HFO-1234ze(E);
- (2) from about 13% by weight to about 25% by weight of ethanol;
- and (3) ipratropium bromide;
- and
- iii. a metering valve releasably closing the canister and having orifice diameter of less than 0.5 mm;
- and
- b. actuating said pMDI to produce an aerosol spray of said ipratropium bromide.
7 more elements
A pharmaceutical composition in the form of an aerosol spray comprising particles comprising ipratropium bromide and wherein greater than about 40% by weight of said spray of particles are particles having a size of 5 microns or less.
Dependencies are inferred from the claim text.