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US 2026/0076885 A1Published application
Complexation of Oxybenzone with C-methylresorcin[4]arene
AssigneeUniversity of Cincinnati
InventorsHarshita Kumari, Xu Kang
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AssigneeUniversity of Cincinnati
InventorsHarshita Kumari, Xu Kang
Estimating the term…
The present invention involves the formation of host-guest complexes between C-methylresorcin[4]arene and Oxybenzone (OXB). NMR spectroscopy confirmed the formation of a weak host-guest complex and molecular dynamics docking simulations indicated that this complex likely had a 1:1 stoichiometry. Furthermore, skin permeation testing revealed that complexation by C-methylresorcin[4]arene significantly reduced the amount of OXB that permeated skin. These results show the potential of supramolecular complexation for improving the stability and decreasing the skin permeability of OXB, thus limiting harmful side effects.
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A method of protecting a subject's skin from sun damage comprising applying a therapeutically effective amount of a composition comprising a cocrystal complex of oxybenzone with C-methylresorcin[4]arene (RsC1) to the skin of the subject.
A method of protecting a subject's skin from sun damage comprising applying a therapeutically effective amount a sunscreen formulation comprising a cocrystal complex of oxybenzone with C-methylresorcin[4]arene (RsC1) to the skin of a subject in need of such treatment;
Dependencies are inferred from the claim text.