Medical tissue wrap
AssigneeTissium
InventorsMarie MALAFOSSE, Julien LAMAZOUADE, Estelle COLLIN, Maria PEREIRA
Life of this patent
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Abstract
A medical tissue wrap, for an internal anatomical structure of a mammal is formed by a coiled wall having a circumferential inner end portion and a circumferential outer end portion extending around and overlapping the circumferential inner end portion. The wall thereby defines a longitudinal through-hole for accommodating a portion of the anatomical structure. The circumferential outer end portion is radially spaced-apart from the circumferential inner end portion by a discontinuous spacing in the circumferential direction. The tissue wrap comprises a structural outer surface modification at opposing longitudinal end portions of its wall.
Claims47
A medical tissue wrap (10) for an internal anatomical structure of a mammal, the tissue wrap (10) being formed by a coiled wall (12) having a circumferential inner end portion (20) and a circumferential outer end portion (22) extending around and overlapping the circumferential inner end portion (20) thereby defining a longitudinal through-hole (16) for accommodating at least one portion of the internal anatomical structure, wherein the circumferential outer end portion (22) is radially spaced-apart from the circumferential inner end portion (20) by a discontinuous spacing in the circumferential direction and the circumferential outer end portion (22) is not in any direct contact with the circumferential inner end portion (20).
The medical tissue wrap (10) according to any one of the preceding claims, wherein the radial spacing (24) at a circumferential end face (28′) of the circumferential inner end portion (20) is less than the radial spacing (24) at a circumferential end face (28) of the circumferential outer end portion (22).
The medical tissue wrap (10) according to any of the preceding claims, wherein a maximum radial spacing (38) of the discontinuous spacing is from 100 μm to 350 μm, preferably from 150 μm to 250 μm.
The medical tissue wrap (10) according to any of the preceding claims, wherein the circumferential extension (40) of the circumferential outer end portion (22) corresponds to from 10 degrees to 100 degrees of the outer circumference of the tissue wrap (10), preferably from 20 degrees to 90 degrees.
A medical tissue wrap (10) for an internal anatomical structure of a mammal, the tissue wrap (10) being formed by a coiled wall (12) having a circumferential inner end portion (20) and a circumferential outer end portion (22) extending around and overlapping the circumferential inner end portion (20) thereby defining a longitudinal through-hole (16) for accommodating a portion of the internal anatomical structure, wherein the circumferential outer end portion (22) is radially spaced-apart from the circumferential inner end portion (20) and wherein the wall (12) comprises a structural outer surface modification at least at one opposing longitudinal end portions (18) of the wall (12).
The medical tissue wrap (10) according to any of the preceding claims, the medical tissue wrap (10) being configured to accommodate neural tissue, preferably a lesioned peripheral nerve, more preferably a proximal end and distal end of a lesioned single peripheral nerve.
The medical tissue wrap (10) according to any of the preceding claims, wherein circumferential outer end portion (22) is formed by a single wall layer overlapping the circumferential inner end portion (20).
The medical tissue wrap (10) according to any of the preceding claims, wherein the wall (12) is coiled only in a circumferential direction
The medical tissue wrap (10) according to any of the preceding claims, wherein the circumferential inner end portion (20) and the circumferential outer end portion (22) are arranged at circumferentially opposing end portions (20, 22) of the wall (12).
The medical tissue wrap (10) according to any of the preceding claims, wherein the wall (12) is at least partially uncoilable and recoilable in a circumferential direction.
The medical tissue wrap (10) according to any of the preceding claims, wherein the wall (12) is at least partially formed of a resilient or elastic material, preferably of a three-dimensionally printable material.
The medical tissue wrap (10) according to any of the preceding claims, wherein the wall (12) comprises a thickness (30) from 50 μm to 400 μm, preferably from 150 μm to 250 μm.
The medical tissue wrap (10) according to any of the preceding claims, wherein the wall (12) is formed of a biocompatible material, an inert material, a bioimplantable material, and/or a biodegradable material.
The medical tissue wrap (10) according to any of the preceding claims, wherein the wall (12) is formed of a polymer-based material, preferably an elastomer.
The medical tissue wrap (10) according to any of the preceding claims, wherein the wall (12) is formed of a polymerized and/or crosslinked polymer unit, preferably comprising an ester group component and an acid ester group component, wherein the ester group component is preferably a polyol and/or the acid ester group component is preferably a polyacid.
The medical tissue wrap (10) according to any of the preceding claims formed by a 3D-printing process.
Use of a medical tissue wrap (10) according to any of the preceding claims for repairing, supporting, and/or guiding neural tissue, in particular for repairing a peripheral nerve lesion.
A method of treating a peripheral nerve lesion, comprising the steps of:
- providing a medical tissue wrap according to any of the preceding claims;
- uncoiling the wall of the medical tissue wrap so as to provide a circumferential gap between a circumferential end face of the circumferential inner end portion and a circumferential end face of the circumferential outer end portion;
- inserting the lesioned nerve into the medical tissue wrap via said gap;
- and
- securing the lesioned nerve within the wall by recoiling the wall.
A method of supporting a nerve, comprising the steps of:
- providing a medical tissue wrap according to any of the preceding claims;
- uncoiling the wall of the medical tissue wrap so as to provide a circumferential gap between a circumferential end face of the circumferential inner end portion and a circumferential end face of the circumferential outer end portion;
- inserting the nerve to be supported into the medical tissue wrap via said gap;
- and
- securing the nerve to be supported within the wall by recoiling the wall.
Dependencies are inferred from the claim text.