Computer System for Computer Aided Design (CAD) Modeling of a Mitral Valve

A computer system for generating a patient specific computer-aided design (CAD) model of a mitral valve, the computer system comprising:

• one or more processors;
• and a memory storing instructions that when executed by the at least one processor cause the at least one processor to perform operations comprising:
• receiving one or more digital images of a mitral valve of a patient;
• segmenting the one or more digital images to identify structures of the mitral valve;
• generating a CAD model of the mitral valve, the CAD model comprising data for modeled structures representing the identified structures of the mitral valve;
• connecting, in the CAD model, one or more first ones of the modeled structures to one or more second ones of the modeled structures and third ones of the modeled structures, the one or more first ones connecting to the one or more second ones and third ones at multiple locations;
• determining one or more first loading conditions for the modeled structures in the CAD model using a first hemodynamics model;
• simulating movement of the modeled structures in the CAD model based on the first loading conditions applied to the modeled structures;
• determining a specified area based on the CAD model;
• determining one or more second loading conditions using a second hemodynamics model that receives data representing the specified area as an input;
• and
• calibrating the CAD model by modifying a configuration of one or more first ones of the modeled structures and one or more second ones of the modeled structures in the CAD model, with the modifying based on (i) the one or more second loading conditions determined using the second hemodynamics model, and (ii) positions of the modeled structures in the CAD model based on the movement of the modeled structures in the CAD model in comparison to positions of the identified structures.

One or more non-transitory, computer readable storage media storing instructions for generating a patient specific computer-aided design (CAD) model of a mitral valve, the instructions when executed by at least one processor cause the at least one processor to perform operations comprising:

• receiving one or more digital images of a mitral valve of a patient;
• segmenting the one or more digital images to identify structures of the mitral valve;
• generating a CAD model of the mitral valve, the CAD model comprising data for modeled structures representing the identified structures of the mitral valve;
• connecting, in the CAD model, one or more first ones of the modeled structures to one or more second ones of the modeled structures and third ones of the modeled structures, the one or more first ones connecting to the one or more second ones and third ones at multiple locations;
• determining one or more first loading conditions for the modeled structures in the CAD model using a first hemodynamics model;
• simulating movement of the modeled structures in the CAD model based on the first loading conditions applied to the modeled structures;
• determining a specified area based on the CAD model;
• determining one or more second loading conditions using a second hemodynamics model that receives data representing the specified area as an input;
• and
• calibrating the CAD model by modifying a configuration of one or more first ones of the modeled structures and one or more second ones of the modeled structures in the CAD model, with the modifying based on (i) the one or more second loading conditions determined using the second hemodynamics model, and (ii) positions of the modeled structures in the CAD model based on the movement of the modeled structures in the CAD model in comparison to positions of the identified structures.