Method and Device for Whole Organ Pulsed Electric Field Application for Irreversible Electroporation

A system comprising:

• an expandable electrode catheter comprising:
• a tubular member having a first end and a second end;
• and
• a plurality of electrodes comprising at least 4 electrodes including a first electrode and a second electrode, the plurality of electrodes housed in the first end of the tubular member and configured (i) to be stowed within the tubular member in a first configuration and (ii) to extend out of the tubular member, via movement of the tubular member or movement of the plurality of electrodes, to be in a second configuration,
• wherein during deployment the first electrode extends in a first angular direction and second electrode extends in a second angular direction opposite to the first angular direction so each come into proximity or contact with a surface tissue of a hollow or tubular organ to fill a shape of the hollow or tubular organ,
• wherein each of the plurality of electrodes is configured to uniformly directly or indirectly emit a plurality of electrical pulses in a liquid medium (e.g., while in contact with the tissue or only through the liquid medium) to penetrate at least a pre-defined depth into the surface tissue as a pulsed electric field application to induce a tissue response (e.g., irreversible electroporation and subsequent exfoliation, electroporation, pulsed field ablation, cell stimulation, and other non-thermal ablation) of at least the surface tissue of the hollow or tubular organ.