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US 2026/0076346 A1Published application
Immunodeficient non-human animals for assessing drug metabolism and toxicity
AssigneeUniversity of Dundee
InventorsRoland WOLF, Colin HENDERSON
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Abstract
The present invention relates to an immunodeficient non-human animal where endogenous drug metabolising enzymes and transcription factors are substantially inactivated. In some aspects of the invention, the animal expresses human drug metabolising enzymes and associated transcription factors. There is also provided related methods of generating the animal of the invention. Additionally, there is provided methods of performing preclinical drug studies using the animal of the invention.
Claims41
An immunodeficient non-human animal wherein at least one endogenous drug metabolism enzyme has been substantially inactivated.
Dependencies are inferred from the claim text.