Methods and systems for individual ion mass spectrometry
AssigneeNorthwestern University
InventorsJohn P. McGee, Bryon Shane Drown, Jared Otto Kafader, Neil L. Kelleher, Philip D. Compton
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Abstract
Disclosed herein are methods and systems for individual ion mass spectrometry (I2MS). The methods and systems described herein parse I2MS data and allows for informed tandem mass spectrometry analyses by determining a target m/z that increases the yield of an intact mass corresponding to an analyte of interest while reducing the yield of additional detectable masses.
Claims21
A method for determining a target m/z, the method comprising:
- producing, with an ion source, ions of a sample, each of the ions having a mass-to-charge (m/z) ratio;
- generating, with a detector, detector signals corresponding to the m/z ratios of ions in the sample;
- and
- determining, with a controller, the target m/z, wherein the target m/z is selected for an intact-mass corresponding to an analyte of interest.
A method for determining a mass spectrum, the method comprising:
- producing, with an ion source, ions of a sample, each of the ions having a mass-to-charge (m/z) ratio;
- generating, with a detector, detector signals at a target m/z, wherein the target m/z is selected for an intact-mass corresponding to an analyte of interest;
- and
- determining, with a mass analyzer, a mass spectrum for the target m/z.
A method for generating a target mass report, the method comprising:
- producing, with an ion source, ions of a sample, each of the ions having a mass-to-charge (m/z) ratio;
- generating, with a detector, detector signals corresponding to the m/z ratios of ions in the sample;
- and
- generating, with a controller, a target mass report, wherein the target mass report comprises a target mass for an analyte of interest, one or more target m/z for the target mass of the analyte of interest, a charge state for each of the one of more target m/z, and, if present, additional detectable masses for each target m/z.
Dependencies are inferred from the claim text.